(Blood-brain barrier, BBB)
Cov ntshav-hlwb teeb meem yog ib qho tseem ceeb ntawm kev tiv thaiv tus kheej hauv tib neeg.Nws yog tsim los ntawm lub paj hlwb capillary endothelial hlwb, glial hlwb, thiab choroid plexus, tso cai rau tsuas yog hom molecules ntawm cov ntshav nkag mus rau lub hlwb neurons thiab lwm cov hlwb nyob ib puag ncig, thiab tuaj yeem tiv thaiv ntau yam teeb meem los ntawm kev nkag mus rau lub hlwb.Lub hlwb, ua ib feem tseem ceeb ntawm tib neeg lub cev, tswj ntau yam haujlwm tseem ceeb.Cov kab mob ntshav-hlwb tuaj yeem thaiv cov khoom tsis zoo hauv cov ntshav thiab tiv thaiv kev nyab xeeb ntawm lub hlwb.
Alzheimer's disease, AD
Alzheimer's disease (AD) yog ib qho kab mob neurodegenerative uas muaj qhov tshwm sim tsis zoo.Hauv kev xyaum kho mob, kev dementia tag nrho yog tus cwj pwm los ntawm kev tsis nco qab, aphasia, aphasia, poob ntawm kev paub, kev tsis pom kev thiab kev txawj ntse, kev ua haujlwm tsis zoo, thiab kev hloov tus cwj pwm thiab kev coj cwj pwm.Lub etiology tseem tsis paub.Premature dementia yog hais txog cov neeg uas muaj cov tsos mob ua ntej hnub nyoog 65 xyoos;Cov tib neeg uas muaj dementia tom qab hnub nyoog 65 xyoos raug xa mus rau senile dementia.Qhov tshwm sim ntawm Alzheimer's kab mob (AD) feem ntau cuam tshuam nrog β- Amyloid protein (A β) Kev sib txuam thiab Tau protein entanglement txuas, thiab kev tshawb fawb ntau ntxiv yog maj mam sau cov neuroinflammation ua ib qho ntawm cov txiaj ntsig ua rau qhov tshwm sim ntawm AD.
Lus Nug: Alzheimer's disease yog dab tsi?Ua tib zoo saib qhov kev paub no.Cov Neeg Txhua Hnub Online.2023-09-20 IB
Nco ntsoov tias muaj ib hom kab mob tuaj yeem nkag mus rau hauv cov ntshav-hlwb barrier
Tsis ntev los no, cov kws tshawb fawb los ntawm Baylor College of Medicine hauv Tebchaws Meskas tau luam tawm cov ntaub ntawv tshawb fawb hu ua: Tus xov tooj hu zoo li receptor 4 thiab CD11b qhia txog microglia kev tswj xyuas ntawm Candida albicans cerebral mycosis hauv Cell Reports sub journal.
Peb tau tshawb pom cov kab mob hu ua Candida albicans uas tuaj yeem nkag mus rau hauv lub hlwb los ntawm cov hlab ntsha.Raws li cov lus tshaj tawm hais tias, "Kev ncaws taw ntawm tus neeg ua tsis taus pa tuaj yeem ua rau Alzheimer's tus kab mob zoo li hloov pauv."Hauv txoj kev tshawb no, peb tau qhia ntxiv txog cov txheej txheem molecular uas Candida albicans tawg los ntawm cov hlab ntsha-hlwb thiab nkag mus rau hauv lub hlwb, ua rau Alzheimer's kab mob xws li kev hloov pauv.
Candida albicans nkag mus rau hauv lub hlwb li cas?"Peb pom tias Candida albicans tsim ib qho enzyme hu ua secreted aspartate protease (Saps), uas cuam tshuam cov hlab ntsha-hlwb barrier, cia cov fungi nkag mus rau hauv lub hlwb thiab ua rau puas," said Dr. Yifan Wu, tus kws tshawb fawb tom qab kws kho mob ua haujlwm ntawm Corry. Laboratory.
Candida albicans
Candida albicans (lub npe scientific: Candida albicans) yog cov poov xab uas tuaj yeem ua rau muaj kev pheej hmoo kis mob.Nws yog feem ntau pom nyob rau hauv cov kab mob hauv zej zog ntawm tib neeg digestive thiab urogenital tracts.Kwv yees li 40% txog 60% ntawm cov neeg laus noj qab haus huv muaj Candida albicans hauv lawv qhov ncauj thiab plab hnyuv.Candida albicans feem ntau koom nrog tib neeg lub cev, tab sis tuaj yeem loj hlob thaum lub cev tsis muaj zog thiab ua rau candidiasis.Nws yog cov kab mob pathogenic tshaj plaws hauv Candida genus
Raws li kev tshawb fawb hauv Cell Reports, cov kab mob uas peb feem ntau tsis mloog ntau tuaj yeem yog ib qho ntawm cov neeg ua txhaum ntawm Alzheimer's disease.Cov kws tshawb fawb los ntawm Baylor Lub Tsev Kawm Ntawv Tshuaj thiab cov koom haum koom tes tau tshawb pom los ntawm cov qauv tsiaj li cas Candida albicans nkag mus rau hauv lub hlwb thiab yuav ua li cas nws qhib ob lub tswv yim ywj pheej hauv hlwb hlwb uas txhawb nqa nws qhov kev tshem tawm (uas yog qhov tseem ceeb rau kev nkag siab txog kev txhim kho Alzheimer's kab mob), thiab tau tsim. β Amyloid protein (A β) Peptides (cov tshuaj lom neeg tawg ntawm amyloid protein) raug suav hais tias yog lub hauv paus ntawm kev loj hlob ntawm Alzheimer's disease.
Dr. David Corry hais.David Corry yog tus Thawj Coj ntawm Pathology ntawm Fulbright Foundation thiab tus xibfwb ntawm pathology, immunology, thiab tshuaj ntawm Baylor University.Nws kuj yog ib tug tswv cuab ntawm Baylor L. Duncan Comprehensive Cancer Center.Xyoo 2019, peb pom tias Candida albicans tau nkag mus rau hauv lub hlwb thiab tsim cov kev hloov pauv zoo ib yam li Alzheimer's disease.Kev mob tshwm sim los ntawm Candida albicans feem ntau nrog
A β Qhov laj thawj rau kev tsim cov amyloid zoo li peptides yog tias Sap tuaj yeem hydrolyze amyloid precursor proteins (APPs).
Txawm li cas los xij, cov peptides no tseem nyiam cov xim ntawm lub hlwb tiv thaiv kab mob - microglia, uas yog qhov tseem ceeb rau kev tshem tawm tom ntej ntawm Candida albicans los ntawm lub hlwb nws tus kheej.Tsis tas li ntawd, cov tshuaj lom Candidalysin tsim los ntawm Candida albicans activates microglia los ntawm lwm txoj kev.Yog tias txoj kev no cuam tshuam, cov kab mob hauv lub hlwb tsis tuaj yeem raug tshem tawm.
Cov kws tshawb fawb taw qhia tias txoj haujlwm no yuav dhau los ua ib qho kev sib tw tseem ceeb rau kev nkag siab qhov tshwm sim ntawm Alzheimer's disease.Cov kev tshawb fawb yav dhau los tau qhia tias proteases nyob rau hauv lub hlwb muaj kev koom tes hauv kev rhuav tshem cov apps thiab pab txhawb rau A β Cov tsub zuj zuj ntawm tau tso lub hauv paus.Thiab tam sim no nws tuaj yeem lees paub tias qhov exogenous protease los ntawm fungi tuaj yeem ua rau A β Peptide zoo li ntau lawm.
Cov kws tshawb fawb tau taw qhia tias kev soj ntsuam ntxiv ntawm lub luag haujlwm ntawm Candida albicans hauv kev txhim kho Alzheimer's tus kab mob yog xav tau nyob rau yav tom ntej, uas tseem tuaj yeem ua rau cov tswv yim kho tshiab rau AD.
Cov ntaub ntawv siv:
[1] Yifan Wu et al, Tus Xov Tooj zoo li tus txais 4 thiab CD11b tau nthuav tawm ntawm microglia tswj kev tshem tawm ntawm Candida albicans cerebral mycosis, Cell Reports (2023) DOI: 10.1016/j.celrep.2023.113240
[2] Cov khoom lag luam hauv hlwb Alzheimer's kab mob zoo li kev hloov pauv, hais tias txoj kev tshawb fawb tshiab Rov qab Lub Kaum Hli 17, 2023 los ntawm https://medicalxpress.com/news/2023-10-brain-fungal-infection-alzheimer-disease-like.html
Post lub sij hawm: Dec-22-2023